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. 2018 Jan 27;10(2):34. doi: 10.3390/cancers10020034
PDAC Pancreatic ductal adenocarcinoma
PC Pancreatic cancer
CAFs Cancer associated fibroblasts
PSCs Pancreatic stellate cells
ECM Extracellular matrix
MCN Mucinous cystic neoplasms
IPMN Intraductal papillary mucinous neoplasms
PanIN Pancreatic intraepithelial neoplasia
KRAS KRAS proto-oncogene
CDKN2A Cyclin dependent kinase inhibitor 2A
TP53 Tumor protein 53
SMAD4 SMAD family member 4
CNV Copy number variation
ERBB2 Erb-b2 receptor tyrosine kinase 2
MET MET proto-oncogene, receptor tyrosine kinase
CDK6 Cyclin dependent kinase 6
PIK3CA Phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha
PIK3R3 Phosphoinositide-3-kinase regulatory subunit 3
BRCA Breast cancer (susceptibility gene)
PALB2 Partner and localizer of BRCA2
Hh Hedgehog
TGF-β Transcription Growth Factor β
SMAD4 SMAD family member 4
MAPK Mitogen associated protein kinase
TME Tumor microEnvironment
MMPs Matrix metalloProteases
TIMPs Tissue inhibitor metalloproteases
EGF Epidermal growth factor
FAK Focal adhesion kinase
DDR2 Discoidin domain receptor tyrosine kinase 2
NF-κβ Nuclear factor kappa beta
EMT Epithelial-to-mesenchymal transition
SHH Sonic Hedgehog
SPOCK Sparc/osteonectin, cwcv and kazal-like domains proteoglycan
HA Hyaluronic acid
CD44 Cluster of differentiation 44
RHAMM Receptor for HA mediated motility
CAM-DR Cell adhesion mediated drug resistance
ROCK Rho-associated protein kinase
ECs Endothelial cells
vSMCs Vascular smooth muscle cells
VEGF Vascular endothelial growth factor
bFGF basic fibroblast growth factor
HIF1α Hypoxia inducible factor 1α
CypA Cyclophilin A
LDH-A Lactate dehydrogenase A
ROS Reactive oxygen species
TCA cycle Tricarboxylic acid cycle
FSP1 Fibroblast specific protein 1
α-SMA α-Smooth muscle actin
BMDCs Bone marrow derived cells
GFAP Glial fibrillary acidic protein
IL Interleukin
TNFα Tumor necrosis factor α
PDGF Platelet derived growth factor
TAM Tumor associated macrophage
NE Neutrophil elastase
NET Neutrophil Extracellular Traps
NLR Neutrophil to lymphocyte Ratio
TIL Tumor infiltrating lymphocytes
NMF non-negative matrix factorization
QM Quasi mesenchymal
GEP Gene expression profiles
ADEX Aberrantly differentiated endocrine exocrine
TCGA The Cancer Genome Atlas