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. 2018 Feb 3;10(2):41. doi: 10.3390/cancers10020041

Figure 1.

Figure 1

Reporter responsive (RR) cells were significantly more capable in forming mammospheres in the setting of limiting dilutions. Reporter unresponsive (RU) and RR cells derived from MCF7 and ZR751 cells were serially diluted and seeded into low attachment 96-well plates. After 7 days, the spheres were counted and data was analyzed using ELDA software. (A) RR cell subset purified from MCF7 cells had a median frequency of 1/42.3 mammosphere forming cells, as compared to 1/104.6 in the RU subset (p = 0.002); (B) RR cell subset purified from ZR751 cells had a median frequency of 1/66.5 mammosphere forming cells, as compared to 1/183.3 mammosphere forming cells in the RU subset (p = 0.007).