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PERK deficiency in Pck1MC-KO cells. BMDMs isolated and differentiated from Pck1flox/flox and Pck1MC-KO mice (n = 8). A, after treatment with LPS (100 ng/ml) whole cell lysates were made and immunoblotted for the indicated proteins. The values are the mean ± S.E. normalized with 18S rRNA and expressed as -fold difference over Pck1flox/flox. PERK, total PKR-like ER kinase; eIF2α-T, total eIF2α; eIF2α-P, phospho-eIF2α (Ser-51); HSC-70, heat shock cognate 70.
