Figure 1.

The effect of mutation of the Lys³⁸⁶ residue located in the BR of STIM1 on CRAC channel currents. The data shown are the whole-cell inward CRAC channel currents (mean ± S.D., n = 8) measured at −80 mV in WT cells and in the same cells bearing the indicated mutations of the Lys³⁸⁶ residue in STIM1 (n = 6–9). Error bars represent the mean ± S.D. channel currents induced by inclusion of adenophostin A (2 μm) in the patch pipette solution with individual measurements indicated by open circles.