Figure 4.

The effects of mutations of the Leu³⁹⁰ residue in STIM1 on adenophostin-activated CRAC channel currents and AA-activated ARC channel currents compared with the same in the wildtype channels. Data shown are individual measurements (circles) of inward currents (with mean ± SD, n = 6–9, indicated by error bars) measured at −80 mV in cells expressing the wildtype STIM1 or STIM1 bearing the indicated mutations of the Leu³⁹⁰ residue. ARC channel and CRAC channel currents were activated by standard procedures (see “Experimental procedures”).