Table 2.

Secular trends on birth parameters and growth (mean ± SD).

Birth year	Before 1980	1980–1984	1985–1989	1990–1994	1995–1999	2000–2004	p-Value
At birth
N = [birth weight(BW)/birth length (BL)]	769/492	1163/777	1552/1123	1409/992	948/688	531/428
BW SD score (SDS)	−1.18 ± 1.18	−1.11 ± 1.20	−1.04 ± 1.20	−1.00 ± 1.18	−0.99 ± 1.17	−1.00 ± 1.16	<0.001
BL SDS	–0.97 ± 1.42	−0.83 ± 1.38	−0.84 ± 1.41	−0.78 ± 1.38	−0.78 ± 1.53	−1.00 ± 1.37	<0.001
Midparental height SDS	−0.82 ± 1.17	−0.65 ± 1.17	−0.44 ± 1.14	−0.44 ± 1.16	−0.37 ± 1.17	−0.29 ± 1.16	<0.001
At GHT start (cohort #1a)
N =	855	1306	1729	1621	1107	601
Age (years)	12.68 ± 2.01	10.85 ± 2.93	9.70 ± 3.33	8.83 ± 3.44	7.43 ± 3.24	5.26 ± 2.39	<0.001
Height SDS (Prader)	−3.72 ± 1.05	−3.42 ± 1.02	−3.28 ± 0.95	−3.15 ± 0.98	−3.04 ± 1.22	−2.97 ± 1.13	<0.001
Height SDS (Ranke)	−0.05 ± 01.12	0.10 ± 1.10	0.21 ± 1.05	0.25 ± 1.07	0.30 ± 1.29	0.32 ± 1.08	<0.001
Δ Height − MPH SDS	−2.90 ± 1.11	−2.77 ± 1.18	−2.79 ± 1.16	−2.68 ± 1.19	−2.65 ± 1.37	−2.68 ± 1.23	<0.01
Weight SDS	−1.59 ± 1.31	−1.47 ± 1.32	−1.35 ± 1.30	−1.33 ± 1.36	−1.40 ± 1.40	−1.65 ± 1.38	NS
Body mass index (BMI) SDS	0.42 ± 1.08	0.37 ± 1.13	0.41 ± 1.16	0.39 ± 1.21	0.28 ± 1.17	−0.04 ± 1.21	NS
At age 8 years (cohort #1b)
N =	18	226	287	280	178	102
Height SDS (Prader)	−2.69 ± 0.79	−2.41 ± 0.79	−2.22 ± 0.77	−2.14 ± 0.78	−2.08 ± 0.86	−1.96 ± 0.87	<0.001
Height SDS (Ranke)	−0.44 ± 1.01	0.13 ± 1.00	0.10 ± 0.96	0.18 ± 0.98	0.27 ± 1.07	0.39 ± 1.09	<0.001
Δ Height − MPH SDS	−2.86 ± 1.06	−2.83 ± 1.11	−2.79 ± 1.16	−2.81 ± 1.14	−2.71 ± 1.12	−2.55 ± 1.32	NS
Weight SDS	−1.41 ± 1.32	−1.49 ± 1.15	−1.35 ± 1.20	−1.28 ± 1.24	−1.14 ± 1.25	−1.20 ± 1.15	NS
BMI SDS	0.63 ± 1.07	0.35 ± 0.97	0.35 ± 1.06	0.37 ± 1.13	0.48 ± 1.08	0.34 ± 0.95	NS