Table 2.

Top 3 association results based on 2df tests for risk of early-onset bipolar disorder, and 2 subsequent association results for each of the top mtSNPs

mtSNP					nSNP					Association results
SNP	BP	gene	MA	MAF	SNP	Chr: BP	closest gene	MA	MAF	2df p value	interaction p value	OR1	OR2
rs3088309	15,452	CytB	T	0.21	rs583990	2: 80213652	CTNNA2	A	0.25	2.1×10−7	1.6×10−6	1.05	4.53
					rs9933834	16: 70683178	IL34	C	0.34	1.1×10−6	4.7×10−5	1.69	0.60
					rs11122534	1: 230688466	LOC729257	C	0.17	1.4×10−5	2.7×10−4	0.82	0.19
rs3915952	11,251	ND4	C	0.22	rs9933834	16: 70683178	IL34	C	0.34	2.9×10−7	1.1×10−5	1.74	0.58
					rs556003	2: 80216399	CTNNA2	G	0.38	3.1×10−7	3.2×10−7	0.95	3.75
					rs1975145	18: 55931179	NEDD4L	T	0.21	5.4×10−6	1.4×10−6	1.49	0.32
rs3928306	3,010	RNR2	A	0.24	rs2420932	10: 123118218	FGFR2	G	0.18	4.5×10−7	9.4×10−8	1.29	0.20
					rs6597183	6: 6042429	NRN1	T	0.22	1.4×10−6	2.1×10−5	1.07	1.07
					rs7987059	13: 27541625	LOC100129306	T	0.19	1.2×10−5	2.5×10−6	0.66	0.65

MtSNP-nSNP interaction test results are also shown for the same SNP pairs. mtSNP, mitochondrial single-nucleotide polymorphism; nSNP, nuclear single-nucleotide polymorphism; SNP, single-nucleotide polymorphism; BP, base pair; MA, minor allele; MAF, minor allele frequency; Chr, chromosome.

¹In the presence of a major mtSNP allele, OR for adding 1 copy of an nSNP minor allele.

²In the presence of a minor mtSNP allele, OR for adding 1 copy of an nSNP minor allele.