Table 2.

Differentiating features of C3 glomerulopathy and aHUS

	C3 glomerulopathy	aHUS
Clinical features	Hematuria, proteinuria, renal failure	Hematuria, proteinuria, renal failure, thrombocytopenia and anemia
Multi-system involvement	No	Yes
Laboratory parameters	Proteinuria, hematuria, increased BUN and Cr, low GFR	Proteinuria, hematuria, increased BUN and Cr, low GFR Thrombocytopenia (relative or absolute), anemia, low haptoglobin, elevated LDH, schistocytes on peripheral smear can be observed
ADAMTS-13	At present no role in establishing the diagnosis	Important in establishing the diagnosis
Renal biopsy	Required to make the diagnosis	Not required to make the diagnosis
Pathophysiology	Alternate complement pathway dysregulation (fluid phase)	Alternate complement pathway dysregulation (solid phase)
Prognosis	Relatively better prognosis	Worse prognosis with high recurrence
Treatment	Role of complement pathway blockade is controversial	Role of complement blockade established

aHUS, atypical hemolytic uremic syndrome; BUN, blood urea nitrogen; Cr, creatinine; GFR, glomerular filtration rate; LDH, lactate dehydrogenase.