Table 1.
Summary of Patient Demographics and Clinical Characteristics by Third Component of First ART Regimen
| EFV-Based | Boosted PI | Combined | ||
|---|---|---|---|---|
| Characteristics | (n = 12 898) | (n = 1621) | (n = 14 519) | P |
| Age at ART initiation, y | 37 (30–45) | 35 (29–44) | 37 (30–45) | <.001 |
| Male, n (%) | 9864 (76) | 956 (59) | 10 820 (75) | <.001 |
| CD4 at ART initiation, cells/µL | 175 (66–289) | 217 (79–351) | 178 (67–295) | <.001 |
| Missing CD4 at ART, n (%) | 1208 (9) | 203 (13) | 1411 (10) | |
| Late ART initiation, n (%) | 7863 (61) | 804 (49) | 8667 (60) | <.001 |
| Probable route of HIV transmission, n (%) | <.001 | |||
| Heterosexual | 3874 (30) | 665 (41) | 4539 (31) | |
| MSM | 4100 (32) | 529 (33) | 4629 (32) | |
| Other | 130 (1) | 25 (2) | 155 (1) | |
| Unknown | 4794 (37) | 402 (25) | 5196 (36) | |
| NRTI backbone, n (%) | <.001 | |||
| 3TC/ABC | 483 (4) | 126 (8) | 609 (4) | |
| 3TC/AZT | 8234 (64) | 858 (53) | 9092 (63) | |
| 3TC/D4T | 744 (6) | 60 (4) | 804 (6) | |
| 3TC/TDF | 1754 (14) | 351 (22) | 2105 (14) | |
| FTC/TDF | 1683 (13) | 226 (14) | 1909 (13) | |
| Patients per site, n (%) | <.001 | |||
| Argentina | 1680 (13) | 345 (21) | 2025 (14) | |
| Brazil | 2258 (18) | 507 (31) | 2765 (19) | |
| Chile | 1109 (9) | 186 (11) | 1295 (9) | |
| Haiti | 3824 (30) | 234 (14) | 4058 (28) | |
| Honduras | 800 (6) | 26 (2) | 826 (6) | |
| Mexico | 873 (7) | 145 (9) | 1018 (7) | |
| Peru | 2354 (18) | 178 (11) | 2532 (17) | |
| Year of ART initiation | 2009 (2007–2012) | 2011 (2008–2013) | <.001 |
Continuous variables are reported as medians (interquartile range). CCASAnet participating centers per country are: Hospital Fernandez and Centro Medico Huesped in Buenos Aires, Argentina; Instituto de Pesquisa Clinica Evandro Chagas, Fundacão Oswaldo Cruz in Rio de Janeiro, Brazil; Fundación Arriarán in Santiago, Chile; Le Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes in Port-au-Prince, Haiti; Instituto Hondureño de Seguridad Social and Hospital Escuela Universitario in Tegucigalpa, Honduras; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico City, Mexico; and Instituto de Medicina Tropical Alexander von Humboldt in Lima, Peru.
Abbreviations: 3TC, lamivudine; ABC, abacavir; AZT, zidovudine; D4T, stavudine; EFV, efavirenz; FTC, emtricitabine; late ART Initiation, CD4 <200 or AIDS-defining event at ART initiation; MSM, men having sex with men; NRTI, nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; TDF, tenofovir.