Table 2.

Number of retinal ganglion cells per region of interest in the normal and ischemic retinae 7 days after ischemia+Post-C for all the siRNA treatments

	Normal retina	Ischemic retina	p value
Non-silencing siRNA/post-conditioning	10.4±0.9	9.8±0.9	0.40
p38α siRNA/post-conditioning	11.8±0.6	7.9±0.8	0.03
Akt1 siRNA/post-conditioning	11.6±0.4	6.7±0.5	0.03
Akt2 siRNA/post-conditioning	11.3 ±0.9	7.9±0.9	0.04
Akt3 siRNA/post-conditioning	10.6±0.2	7.1±0.4	0.07

Post-conditioning (top row) prevented the loss of retinal ganglion cells; this effect was attenuated by p38α, Akt1, and Akt2 siRNA. Akt3 siRNA caused a decrease that was not significant. Statistical analysis was achieved using the non-parametric Wilcoxon test