Table III. ROC analysis of multimarker models to indicate GDM. GDM, gestational diabetes mellitus; ROC, receiver operating characteristic; AUC, area under the curve; BMI, body mass index; ChE, cholinesterase; RBP4, retinol binding protein 4; Cys C, Cystatin C; C16:1 (cis-7), cis-7-hexadecenoate; 6,7-diketoLCA, 6,7-diketocholic acid.
| Model | Variables included in the model | AUC (95% CI) | p value |
|---|---|---|---|
| Metabolites | |||
| 1 | N-acetylaspartic acid, 2-Oxo-4-methylvaleric acid, C16:1 (cis-7), 6,7-diketoLCA | 0.740 (0.680–0.799) | <0.001 |
| 2 | N-acetylaspartic acid, alanine, C16:1 (cis-7), 6,7-diketoLCA | 0.740 (0.681–0.800) | <0.001 |
| 3 | N-acetylaspartic acid, 1-monooleoyl glycerol, C16:1 (cis-7), 6,7-diketoLCA | 0.738 (0.679–0.798) | <0.001 |
| 4 | N-acetylaspartic acid, C16:1 (cis-7), 6,7-diketoLCA | 0.732 (0.672–0.792) | <0.001 |
| 5 | N-acetylaspartic acid, 1-monooleoyl glycerol, 6,7-diketoLCA, 2-oxo-4-methylvaleric acid | 0.722 (0.661–0.783) | <0.001 |
| 6 | N-acetylaspartic acid, 1-monooleoyl glycerol, C16:1 (cis-7), 2-oxo-4-methylvaleric acid | 0.721 (0.661–0.781) | <0.001 |
| BMI and metabolites | |||
| 7 | BMI, 2-oxo-4-methylvaleric acid, n-acetylaspartic acid, 6,7-diketoLCA | 0.744 (0.685–0.803) | <0.001 |
| 8 | BMI, 2-oxo-4-methylvaleric acid, n-acetylaspartic acid, C16:1 (cis-7) | 0.743 (0.685–0.802) | <0.001 |
| 9 | BMI, 2-oxo-4-methylvaleric acid, C16:1 (cis-7), 6,7-diketoLCA | 0.740 (0.681–0.800) | <0.001 |
| 10 | BMI, n-acetylaspartic acid, alanine, C16:1 (cis-7) | 0.740 (0.681–0.798) | <0.001 |
| 11 | BMI, n-acetylaspartic acid, 1-monooleoyl glycerol, C16:1 (cis-7) | 0.740 (0.681–0.799) | <0.001 |
| 12 | BMI, n-acetylaspartic acid, C16:1 (cis-7) | 0.732 (0.672–0.791) | <0.001 |
| BMI, biochemical markers and metabolites | |||
| 13 | BMI, RBP4, n-acetylaspartic acid, C16:1 (cis-7) | 0.751 (0.693–0.809) | <0.001 |
| 14 | BMI, Cys C, n-acetylaspartic acid, 6,7-diketoLCA | 0.749 (0.691–0.808) | <0.001 |
| 15 | BMI, ChE, n-acetylaspartic acid, C16:1 (cis-7) | 0.748 (0.690–0.806) | <0.001 |
| 16 | BMI, Cys C, n-acetylaspartic acid, C16:1 (cis-7) | 0.747 (0.689–0.805) | <0.001 |
| 17 | BMI, Cys C, RBP 4, n-acetylaspartic acid | 0.743 (0.683–0.803) | <0.001 |
| 18 | BMI, Cys C, n-acetylaspartic acid | 0.731 (0.671–0.792) | <0.001 |
***p < 0.001 from ROC analysis.