Table I. Strains, antibiotic resistance phenotypes and β-lactamase genes identified by whole genome sequencing. CAZ, Ceftazidime; CTX, Cefotaxime; FEP, Cefepime; IPM, Imipenem; MEM, Meropenem; TIC, Ticarcillin.
| Name | Strain |
MICa (μg/ml) of: |
β-lactamase genes determined by WGS |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Other designation | Reference | Penicillins | Cephalosporins |
Carbapenems |
Resident | Acquired | ||||
| TIC | CAZ | CTX | FEP | IPM | MEM | |||||
| Group 1 | ||||||||||
| BM4587 | (10) | 8 | 4 | 8 | 1 | 0,12 | 0.5 | blaOXA-104, blaADC | ||
| CIP 70.34T | ATCC19606 | (20) | 16 | 16 | 32 | 16 | 0,5 | 2 | blaOXA-98, blaADC | |
| NIPH 146 | (23, 26) | 8 | 4 | 16 | 1 | 0,12 | 0,25 | blaOXA-64, blaADC | ||
| NIPH 190 | (23, 26) | 4 | 1 | 8 | 0.5 | 0,12 | 0,12 | blaOXA-65, blaADC | ||
| NIPH 201 | (23, 26) | 8 | 2 | 8 | 1 | 0,12 | 0,25 | blaOXA-51-like, blaADC | ||
| NIPH 329 | (23, 26) | 8 | 4 | 16 | 2 | 0,12 | 0,25 | blaOXA-51-like, blaADC | ||
| NIPH 335 | (23, 26) | 16 | 8 | 32 | 8 | 0,25 | 0.5 | blaOXA-128, blaADC | ||
| NIPH 410 | (23, 26) | 4 | 2 | 4 | 0.5 | 0,12 | 0,12 | blaOXA-88, blaADC | ||
| NIPH 60 | (23, 26) | 8 | 2 | 16 | 1 | 0,25 | 0,25 | blaOXA-69, blaADC | ||
| NIPH 601 | (23, 26) | 16 | 2 | 8 | 0,5 | 0,12 | 0,12 | blaOXA-69, blaADC | ||
| NIPH 615 | (23, 26) | 4 | 2 | 4 | 1 | 0,12 | 0,25 | blaOXA-120, blaADC | ||
| NIPH 67 | (23, 26) | 16 | 8 | 16 | 4 | 0,25 | 0,5 | blaOXA-51-like, blaADC | ||
| NIPH 70 | (23, 26) | 16 | 4 | 8 | 2 | 0,25 | 0,25 | blaOXA-256, blaADC | ||
| NIPH 80 | (23, 26) | 32 | 16 | 32 | 4 | 0,12 | 0,5 | blaOXA-78, blaADC | ||
| NIPH 1669 | (26) | 64 | 32 | 128 | 16 | 0,5 | 4 | blaOXA-71, blaADC** | ||
| BM4704 | 3220 | (29) | 64 | 128 | 512 | 32 | 1 | 2 | blaOXA-132*, blaADC* | |
| NIPH 2061 | (30) | 64 | 128 | 512 | 32 | 8 | 32 | blaOXA-109*, blaADC* | ||
| Group 2 | ||||||||||
| NIPH 24 | (25) | >1024 | 16 | 16 | 16 | 2 | 2 | blaOXA-66, blaADC | blaTEM-1 | |
| NIPH 290 | (23) | >1024 | 64 | 32 | 256 | 0,5 | 2 | blaOXA-69, blaADC | blaTEM-1 | |
| NIPH 527 | RUH 875 | (21, 26) | >1024 | 16 | 16 | 8 | 0,5 | 1 | blaOXA-69, blaADC | blaTEM-1 |
| NIPH 528 | RUH 134 | (21, 26) | >1024 | 8 | 16 | 8 | 0,25 | 1 | blaOXA-66, blaADC | blaTEM-1 |
| BM4701 | AB8 | (29) | 512 | 256 | 64 | 16 | 64 | 32 | blaOXA-64, blaADC | blaGES-14 |
| BM4702 | AB25 | (29) | >1024 | >1024 | >512 | >256 | 16 | 16 | blaOXA-64, blaADC | blaGES-11 |
| BM4703 | 3171 | (29) | >1024 | 4 | 16 | 2 | 16 | 8 | blaOXA-64, blaADC | blaOXA-58 |
| NIPH 1734 | (23) | >1024 | 16 | 32 | 4 | 64 | 32 | blaOXA-132, blaADC | blaOXA-58 | |
| BM4714 | 3142 | (29) | >1024 | 4 | 32 | 8 | 128 | >64 | blaOXA-51, blaADC | blaOXA-24 |
| NIPH 1362 | (23, 25) | >1024 | >1024 | 512 | 64 | 16 | 16 | blaOXA-51-like*, blaADC* | blaOXA-58 | |
| BM4713 | AB4 | (29) | 512 | 128 | >512 | 16 | 64 | >64 | blaOXA-66, blaADC* | blaOXA-72 |
| BM4706 | 3185 | (29) | >1024 | 1024 | >512 | 32 | 32 | 32 | blaOXA-94, blaADC* | blaOXA-23 |
| BM4710 | 3073 | (29) | >1024 | 1024 | 512 | 64 | 64 | 64 | blaOXA-69, blaADC* | blaOXA-23 |
| MRSN 3405 | (28) | >1024 | 256 | 512 | 64 | 64 | >64 | blaOXA-69, blaADC* | blaOXA-23 | |
| AYE | (24) | >1024 | >1024 | >512 | >256 | 1 | 1 | blaOXA-69, blaADC* | blaVEB-1 | |
| Group 3 | ||||||||||
| BM4705 | 3228 | (29) | >1024 | 256 | 128 | 4 | 32 | 64 | blaOXA-132, blaADC* | blaOXA-24, blaTEM-1 |
| BM4709 | 3048 | (29) | >1024 | 1024 | 512 | 64 | 32 | 64 | blaOXA-69, blaADC* | blaOXA-23, blaTEM-1 |
| BM4712 | 3162 | (29) | >1024 | 512 | >512 | 256 | 128 | >64 | blaOXA-66, blaADC* | blaOXA-23, blaTEM-1 |
| ANC 4097 | (27) | >1024 | >1024 | >512 | >256 | 128 | >64 | blaOXA-69, blaADC | blaOXA-23, blaTEM-1, blaNDM-1 | |
| BM4708 | AB20 | (29) | >1024 | >1024 | 512 | 256 | 32 | 32 | blaOXA-69, blaADC | blaOXA-23, blaPER-1 |
| BM4711 | AB18 | (29) | >1024 | >1024 | >512 | 256 | 32 | 32 | blaOXA-69, blaADC | blaOXA-23, blaPER-1 |
| BM4707 | 3221 | (29) | >1024 | 32 | 512 | 64 | 64 | 64 | blaOXA-65, blaADC* | blaOXA-23, blaOXA-58 |
* ISAba1 upstream from the gene.
** ISAba125 upstream from the gene.
a MICs were determined by microdilution.