Table II. Specific biological processes significantly enriched in PD fluid with added AlaGln vs. control.
| Enriched biological processes PD fluid vs. PD fluid with AlaGlna | H.sapiens (20972) | Observed | Expected | Fold enrichment | p valueb |
|---|---|---|---|---|---|
| neutrophil degranulation (GO:0043312) | 483 | 19 | 3.64 | 5.22 | 4.82E-05 |
| neutrophil mediated immunity (GO:0002446) | 497 | 20 | 3.74 | 5.34 | 1.27E-05 |
| myeloid leukocyte mediated immunity (GO:0002444) | 518 | 20 | 3.9 | 5.12 | 2.53E-05 |
| leukocyte mediated immunity (GO:0002443) | 725 | 20 | 5.46 | 3.66 | 5.63E-03 |
| leukocyte degranulation (GO:0043299) | 505 | 19 | 3.8 | 4.99 | 9.76E-05 |
| regulated exocytosis (GO:0045055) | 686 | 26 | 5.17 | 5.03 | 1.25E-07 |
| exocytosis (GO:0006887) | 774 | 27 | 5.83 | 4.63 | 3.09E-07 |
| secretion by cell (GO:0032940) | 963 | 27 | 7.26 | 3.72 | 3.47E-05 |
| single-organism cellular process (GO:0044763) | 9841 | 105 | 74.14 | 1.42 | 4.95E-03 |
| single-organism process (GO:0044699) | 12686 | 123 | 95.57 | 1.29 | 2.33E-02 |
| secretion (GO:0046903) | 1068 | 28 | 8.05 | 3.48 | 7.30E-05 |
| single-organism transport (GO:0044765) | 2521 | 43 | 18.99 | 2.26 | 1.51E-03 |
| single-organism localization (GO:1902578) | 2646 | 45 | 19.93 | 2.26 | 7.61E-04 |
| localization (GO:0051179) | 5375 | 75 | 40.49 | 1.85 | 2.45E-05 |
| transport (GO:0006810) | 4368 | 70 | 32.91 | 2.13 | 2.50E-07 |
| establishment of localization (GO:0051234) | 4499 | 71 | 33.89 | 2.09 | 3.36E-07 |
| vesicle-mediated transport (GO:0016192) | 1748 | 44 | 13.17 | 3.34 | 4.90E-09 |
| neutrophil activation involved in immune response (GO:0002283) | 484 | 19 | 3.65 | 5.21 | 4.98E-05 |
| myeloid cell activation involved in immune response (GO:0002275) | 514 | 19 | 3.87 | 4.91 | 1.29E-04 |
| leukocyte activation involved in immune response (GO:0002366) | 606 | 19 | 4.57 | 4.16 | 1.64E-03 |
| cell activation (GO:0001775) | 1026 | 23 | 7.73 | 2.98 | 2.62E-02 |
| cell activation involved in immune response (GO:0002263) | 610 | 19 | 4.6 | 4.13 | 1.81E-03 |
| myeloid leukocyte activation (GO:0002274) | 565 | 19 | 4.26 | 4.46 | 5.62E-04 |
| neutrophil activation (GO:0042119) | 490 | 19 | 3.69 | 5.15 | 6.06E-05 |
| granulocyte activation (GO:0036230) | 494 | 19 | 3.72 | 5.11 | 6.89E-05 |
| macromolecule localization (GO:0033036) | 2214 | 41 | 16.68 | 2.46 | 3.47E-04 |
| single-organism metabolic process (GO:0044710) | 3572 | 54 | 26.91 | 2.01 | 1.22E-03 |
| mRNA metabolic process (GO:0016071) | 663 | 20 | 4.99 | 4 | 1.40E-03 |
| viral process (GO:0016032) | 610 | 19 | 4.6 | 4.13 | 1.81E-03 |
| symbiosis, encompassing mutualism through parasitism (GO:0044403) | 789 | 24 | 5.94 | 4.04 | 6.09E-05 |
| interspecies interaction between organisms (GO:0044419) | 791 | 24 | 5.96 | 4.03 | 6.39E-05 |
| multi-organism process (GO:0051704) | 2398 | 43 | 18.07 | 2.38 | 3.66E-04 |
| RNA splicing (GO:0008380) | 393 | 15 | 2.96 | 5.07 | 3.10E-03 |
| RNA processing (GO:0006396) | 870 | 21 | 6.55 | 3.2 | 2.38E-02 |
| antigen processing and presentation of exogenous peptide antigen (GO:0002478) | 169 | 10 | 1.27 | 7.85 | 6.63E-03 |
| antigen processing and presentation of exogenous antigen (GO:0019884) | 176 | 10 | 1.33 | 7.54 | 9.52E-03 |
| antigen processing and presentation (GO:0019882) | 218 | 11 | 1.64 | 6.7 | 8.62E-03 |
| antigen processing and presentation of peptide antigen (GO:0048002) | 179 | 10 | 1.35 | 7.42 | 1.11E-02 |
| organic substance transport (GO:0071702) | 2048 | 36 | 15.43 | 2.33 | 1.01E-02 |
| regulation of mRNA splicing, via spliceosome (GO:0048024) | 72 | 7 | 0.54 | 12.9 | 1.29E-02 |
| regulation of mRNA processing (GO:0050684) | 104 | 8 | 0.78 | 10.21 | 1.29E-02 |
| regulation of mRNA metabolic process (GO:1903311) | 135 | 9 | 1.02 | 8.85 | 9.13E-03 |
| protein-lipid complex subunit organization (GO:0071825) | 46 | 6 | 0.35 | 17.31 | 1.40E-02 |
| macromolecular complex subunit organization (GO:0043933) | 1689 | 34 | 12.72 | 2.67 | 9.76E-04 |
| cellular component organization (GO:0016043) | 5242 | 72 | 39.49 | 1.82 | 1.38E-04 |
| cellular process (GO:0009987) | 14882 | 140 | 112.12 | 1.25 | 7.86E-04 |
| cellular component organization or biogenesis (GO:0071840) | 5457 | 74 | 41.11 | 1.8 | 1.28E-04 |
| negative regulation of protein metabolic process (GO:0051248) | 1087 | 24 | 8.19 | 2.93 | 2.02E-02 |
| negative regulation of biological process (GO:0048519) | 4778 | 64 | 36 | 1.78 | 4.22E-03 |
| negative regulation of macromolecule metabolic process (GO:0010605) | 2444 | 39 | 18.41 | 2.12 | 3.47E-02 |
| negative regulation of catalytic activity (GO:0043086) | 866 | 21 | 6.52 | 3.22 | 2.22E-02 |
| positive regulation of RNA splicing (GO:0033120) | 28 | 5 | 0.21 | 23.7 | 2.34E-02 |
| regulation of RNA splicing (GO:0043484) | 110 | 8 | 0.83 | 9.65 | 1.95E-02 |
| biological regulation (GO:0065007) | 11745 | 118 | 88.49 | 1.33 | 7.51E-03 |
| positive regulation of biological process (GO:0048518) | 5400 | 72 | 40.68 | 1.77 | 5.06E-04 |
| macromolecular complex assembly (GO:0065003) | 1448 | 28 | 10.91 | 2.57 | 3.39E-02 |
| cellular component assembly (GO:0022607) | 2254 | 42 | 16.98 | 2.47 | 1.88E-04 |
| cellular component biogenesis (GO:0044085) | 2508 | 44 | 18.89 | 2.33 | 4.56E-04 |
| response to chemical (GO:0042221) | 3897 | 53 | 29.36 | 1.81 | 4.65E-02 |
| multicellular organismal process (GO:0032501) | 6633 | 77 | 49.97 | 1.54 | 4.77E-02 |
asignificantly enriched most specific (boldface) biological processes with significantly enriched parent processes from Gene Ontology, sorted according to p values of the most specific biological processes.
bBonferroni-corrected for multiple testing.