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. 2018 Mar 5;37:46. doi: 10.1186/s13046-018-0699-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Lower expression of CADM2 was observed in HCC samples. a Analysis GEO data (GSE27150) of CADM2 expression levels in HCC and adjacent normal tissues (n = 57). b Kaplan-Meier analysis of median overall survival of patients with different CADM2 expression Kaplan-Meier analysis of median overall survival of patients with different CADM2 expression levels from GEO database (GSE27150, P = 0.0757, Red: High expression CADM2, Blue: Low expression CADM2). c Analysis GEO data (GDS3091) of CADM2 expression levels in HCC patients with venous metastasis (n = 9) and without venous metastasis (n = 11) from GEO data (GDS3091) were analyzed. d Relative CADM2 expression levels in HCC samples were detected by qRT-PCR. (n = 36, P = 0.0226). e CADM2 expression in HCC samples was examined using western blotting. GAPDH was used as a loading control. f qRT-PCR for detecting CADM2 mRNA expression levels in several liver cell lines as indicted. (*P < 0.05; **P < 0.01)