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. 2018 Mar 5;37:46. doi: 10.1186/s13046-018-0699-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — FAK/AKT pathway mediates the effect of miR-10b/CADM2 in HCC metastasis. a Western blotting analysis of indicated proteins in Hep3B cells transfected with pEX-CADM2 or pEX-NC. b Hep3B cells were co-transfected with miR-10b mimic (or NC mimic) and pEX-CADM2 (or pEX-NC). The expression of CADM2, FAK and EMT markers were detected by Western blotting. c Treatment with LY294002 reversed EMT mediated by miR-10b overexpression. GAPDH was used as a loading control. d The cells transfected as in Fig. 6c were used to perform Transwell assays. e Schematic representation of CADM2 actions in HCCs. Data represents mean ± SEM of three independent experiments. Error bars represent SD. (*P < 0.05; **P < 0.01; ***P < 0.001)