Fig.1.

Pridopidine is able to enhance or inhibit dopamine-dependent functions. Graphic illustration of psycho-motor stabilization: In vivo pharmacological studies have consistently demonstrated state dependent behavioral effects of pridopidine; reducing psychomotor activity in hyperactive states, and enhancing activity in hypoactive states. This is proposed to translate to stabilization of both hyper- and hypokinetic motor disturbances in HD; to some extent overlapping with observations of disturbed dopamine transmission over the course of the disease [40].