Table 3.
Human gene | C. elegans gene | Phenotypes | Reference |
PRKN | pdr-1 | ↑DA neuron loss, ↓basal slowing, ↓ethanol avoidance, ↓lifespan, mitochondrial accumulation, ↓stress resistance | Springer et al., 2005 [71]; Ved et al., 2005 [102]; Bornhorst et al., 2014 [81]; Chakraborty et al., 2015 [82]; Kirienko et al., 2015 [83]; Palikaras et al., 2015 [64]; Luz et al., 2015 [84]; Cooper et al., 2017 [53] |
PINK1 | pink-1 | ↓basal slowing, mitochondrial accumulation, ↓stress resistance | Samann et al., 2009 [65]; Kirienko et al., 2015 [83]; Palikaras et al., 2015 [64]; Luz et al., 2015 [84]; Cooper et al., 2017 [53] |
DJ-1 | djr-1.1 | ↓stress resistance, mitochondrial fragmentation | Lee et al., 2012 [93]; Cooper et al., 2017 [53] |
djr-1.2 | ↓stress resistance | Lee et al., 2012 [93] | |
ATP13A2 | catp-6 | ↑DA neuron loss, ↓basal slowing, movement deficit, ↓stress resistance | Cooper and Van Raamsdonk, unpublished data |
DA, dopamine.