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. 2018 Mar 5;19:4. doi: 10.1186/s12868-018-0404-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — OPLS-DA score plot (a) and corresponding coefficient plot (b) derived from the ¹H NMR spectra of extractions of serum obtained from control group (n = 8) and SA group (n = 7). A correlation coefficient of |r| > 0.707 (df = 6) was used as the cut-off value that gave a statistically significant result at the level p < 0.05. The loading maps show the significance of metabolite variations between two classes. Peaks in the positive and negative direction indicate the metabolites that are more abundant in SA group and in the control group respectively