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. 2018 Mar 5;37:45. doi: 10.1186/s13046-018-0720-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CASZ1 inhibits HCC growth and metastasis via inactivating the MAPK/ERK signaling a. 10-Pathway Reporter Array was performed to detect the signaling changes in CASZ1-interfered HCC cells. **P < 0.01. b The expression of critical members and downstream effectors of MAPK/ERK pathway was examined by western blot in HCCLM3^CASZ1, PLC/PRF/5^shCASZ1 and their control cells. c The levels of p-ERK, MMP2, MMP9 and cyclinD1 were determined by western blot in HCCLM3^CASZ1, PLC/PRF/5^shCASZ1 and their control cells treated with U0126 (10 μM) or DMSO control. d-f. HCCLM3^CASZ1, PLC/PRF/5^shCASZ1 and their control cells were treated with U0126 (10 μM) or DMSO control and then subjected to MTT (d), wound healing (e) and transwell invasion (f) assays