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. 2018 Mar 5;37:45. doi: 10.1186/s13046-018-0720-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — RAF1 is critical for CASZ1-mediated inhibition of MAPK/ERK signaling and HCC progression a. Western blot analysis of CASZ1, RAF1, p-ERK, MMP2, MMP9 and cyclinD1 expression in CASZ1-interfered HCC cells with RAF1 knockdown or ectopic expression. b-d. MTT (b), wound healing (c) and transwell invasion (d) assays were performed to test the influence of RAF1 on the proliferation, migration and invasion abilities of CASZ1-interfered HCC cells with RAF1 knockdown or ectopic expression. e Schematic depiction of the mechanism underlying CASZ1-mediated inhibition of HCC cell proliferation, migration and invasion based on our study