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. Author manuscript; available in PMC: 2018 Mar 5.
Published in final edited form as: Urology. 2016 Mar 2;91:143–149. doi: 10.1016/j.urology.2015.12.089

Table 2.

Statistical performance characteristics of two biopsy methods in G4 detection

Parameter Saturation Biopsy (N = 106)
Twelve-core Biopsy (N = 269)
Estimate 95% CI Estimate 95% CI P Value
Sensitivity 0.725 0.604–0.825 0.695 0.624–0.760 .648
Specificity 0.919 0.781–0.983 0.976 0.915–0.997 .173
ROC area 0.82   0.75–0.89 0.84   0.80–0.87
NPV 0.642 0.498–0.769 0.584 0.497–0.667 .467
PPV 0.943 0.843–0.988 0.985 0.946–0.998 .143
Upgrade rate (3 + 3 = 6 on biopsy that had G ≥ 4 on RP) 0.358 (19/53) 0.416 (57/137) .467
Downgrade rate (G4 on biopsy that had 3 + 3 = 6 on RP) 0.057 (3/53) 0.015 (2/132) .143

CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic; other abbreviation as in Table 1.