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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Cell Stem Cell. 2018 Mar 1;22(3):369–383.e8. doi: 10.1016/j.stem.2018.02.004

Figure 7. Proposed model for the dynamic feedback between translation, chromatin and transcription in ESCs.

Figure 7

(A) The permissive chromatin state of ESCs promotes growth by sustaining hypertranscription and ribogenesis, whereas growth promotes the permissive chromatin state by sustaining high levels of translational output. Signaling and nutrient sensors such as mTor act as rheostats of this positive feedback loop. (B) The permissive chromatin state of ESCs responds rapidly to changes in translational output, in part due to the instability of euchromatin regulators. See Discussion for details.