Table 1.

Information on devices available for intracranial aneurysm management

Device picture	Device name	Manufacture	CE Mark and FDA approval	Korea/China/Japan market	Brief introduction	On-going clinical trials
Figure 2 A-D	The Woven Endo-Bridge (WEB)	Sequent Medical, Aliso Viejo, CA, USA (http://www.sequentmedical.com/index.html)	CE Mark (2011); USA (investigational use)	China, clinical trial; Korea and Japan, NA	WEB is a self-expanding mesh that can be introduced into intracranial aneurysms and cover the neck of the aneurysm, resulting in blood flow disruption, thrombosis, and occlusion.	CLinical Assessment of WEB® Device in Ruptured aneurYSms (CLARYS) (NCT02687607)
Figure 2 E, F	Medina embolization device (MED)	Covidien/eV3, Medtronic, Dublin, Ireland (https:// www.ev3.net/neuro/us/)	CE Mark (2014)	NA	MED is a three-dimensional coil with a memory shape, comprising a radiopaque platinum core wire and a braid mesh with petals shape attached to each loop of the core wire.	Medina Embolization Device In Neurovascular Aneurysm Study (MEDINA) (NCT02982200)
Figure 2 G, H	Barrel vascular remodeling device (VRD) system	Medtronic, Minneapolis, MN, USA (https://www.ev3.net/neuro/us/)	CE Mark (2013)	NA	Barrel is a self-expandable laser-cut stent with a bulged center section designed to treat wide-necked bifurcation aneurysms with a single stent.	The Reverse Barrel™ VRD Intracranial Aneurysm Trial (Barrel) (NCT02125097)
Figure 2 I-L	PulseRider	Pulsar Vascular (Codman Neuro), Los Gatos, CA, USA (http://www.pulsarvascular.com/)	CE Mark (2013)	NA	PulseRider is a self-expanding nitinol implant designed for treating wide-neck aneurysms arising at vascular bifurcations.	Adjunctive Neurovascular Support for Wide-neck Aneurysm Embolization and Reconstruction (ANSWER) (NCT02312856)
Figure 2 M, N	pCONus	Phenox, Bochum, Germany (http://www.phenox.net/)	CE Mark (2014)	NA	The pCONus is a stent designed to treat wide-neck intracranial bifurcation aneurysms.	pCONus Treatment of Wide-Neck Intracranial Aneurysms (pToWin) (NCT02554708)
Figure 2 O, P	pCANvas	Phenox, Bochum, Germany (http://www.phenox.net/)	NA	NA	pCANvas is an evolution of the pCONus, with additional membrane coverage of the petals (arrows).	NA
Figure 2 Q	Comaneci	Rapidmedical, Yokneam, Israel	CE Mark (2014)	NA	The Comaneci device is a compliant radiopaque mesh, comparable to a compliant balloon in aneurysm coiling, without the drawback of blocked flow within the parent artery during expansion of the device.	NA
Figure 2 R-T	eCLIPs	Evasc Medical Systems Corp., Vancouver, BC, Canada (https://www.evasc.com/)	CE Mark (2014); FDA Designating Humanitarian Use Device (2015)	NA	The eCLIPs is a self-expanding, non-circumferential device designed for treating wide-necked bifurcation aneurysms. It has coil retention and flow-disrupting functions.	European eCLIPs™ Safety, Feasibility and Efficacy Study (EESIS) (NCT02607501)
Figure 2 U-W	Honeycomb microporous covered stent	Corresponding author: Yasuhide Nakayamany@ncvc.go.jp	NA	Japan, clinical trial	The novel honeycomb microporous covered stents were developed for treating large or wide-necked cerebral aneurysms, with the cavernous sinus portion of the internal carotid and vertebrobasilar arteries as the target treatment regions.	Safety and Efficacy of Honeycomb Microporous Covered Stents (NCVC-CS1) for the Treatment of Intracranial Aneurysms (NCVC-CS1_UAN) (NCT02907229)

CE Mark, European Conformity Mark; FDA, U.S. Food and Drug Administration; NA, not available.