Table 5:
Results for Time Spent Outside of Target Glycemic Range
| Author, Year | Measure of Glucose Variability | Results | Difference | P-value | |
|---|---|---|---|---|---|
| Intervention | Control | ||||
| Time Spent in Hypoglycemic Range, Adult Population, RCTs | |||||
| Beck et al, 201724a | Median minutes per day in hypoglycemia (< 60 mg/dL) | 20 (IQR 9–30) | 40 (IQR 16–68) | −20 | .002b |
| Hermanides et al, 201127 | Mean % of time in hypoglycemia (< 4.0 mmol/L) | 2.7 (SE 0.53) | 2.5 (SE 0.6) | LSM difference at baseline and end of study: 0.2 (95% CI −1.6 to 1.7) | .96 |
| Ly et al, 201333a | Median % of time in hypoglycemia (< 60 mg/dL) | Dayc: 1.5 (IQR 0.9–3.7) Nightc: 2.4 (IQR 0.4–5.3) | Dayc: 3.3 (IQR 1.6–5.9) Nightc: 6.2 (IQR 4.2–9.9) | Dayc: −1.8 Nightc: −3.8 | Dayc: .01b Nightc: < .001b |
| van Beers et al, 201639a | Mean hours per day in hypoglycemia (≤ 3.9 mmol/L) | 1.6 (95% CI 1.3–2.0) | 2.7 (95% CI 2.4–3.1) | Mean difference −1.1 (95% CI −1.4 to −0.8) | < .001 |
| Time Spent in Hyperglycemic Range, Adult Population, RCTs | |||||
| Beck et al, 201724a | Median minutes per day in hyperglycemia (> 250 mg/dL) | 223 (IQR 128–383) | 347 (IQR 241–429) | −124 | < .001b |
| Hermanides et al, 201127 | Mean % of time in hyperglycemia (> 11.1 mmol/L) | 21.6 (SE 1.91) | 38.2 (SE 3.58) | LSM difference between groups at baseline and end of study: −17.3 (95% CI −25.1 to −9.5) | < .001 |
Abbreviations: CI, confidence interval; IQR, interquartile range; LSM, least square mean; RCT, randomized controlled trial; SE, standard error.
a
Select results are presented; additional thresholds and permutations of similar results are available in the original study.
b
Authors reported the P-value for the mean difference; the comparison is for the median difference.
c
Day, 6 a.m. to 10 p.m.; night, 10 p.m. to 6 a.m.