Table A8:
Relative Risk Reduction and Relative Risk Associated With a 1% Reduction in A1C Level
| Complication | RR | RRR | 1% Reduction in A1C | Source | |||
|---|---|---|---|---|---|---|---|
| RR | RRR | RR (%) | RRR (%) | ||||
| Retinopathy | 0.462 | 0.538 | 0.025 | 0.029 | 2.5 | 2.9 | DCCT, 199364 |
| Nephropathy | 0.611 | 0.389 | 0.033 | 0.021 | 3.3 | 2.1 | DCCT, 199364 |
| Neuropathy | 0.390 | 0.610 | 0.021 | 0.033 | 2.1 | 3.3 | DCCT, 199364 |
| Cardiovascular disease | 0.643 | 0.357 | 0.034 | 0.019 | 3.4 | 1.9 | Martin et al, 201482 |
| Severe hypoglycemiaa | 1.13 | −0.13 | 0.061 | −0.007 | 6.1 | −0.7 | DCCT, 200976 |
Abbreviations: A1C, glycated hemoglobin; DCCT, Diabetes Control and Complications Trial; RR, relative risk; RRR, relative risk reduction.
a
The risk of severe hypoglycemia increases as A1C is reduced.