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. 2018 Feb 21;18(2):1–160.

Table A8:

Relative Risk Reduction and Relative Risk Associated With a 1% Reduction in A1C Level

Complication RR RRR 1% Reduction in A1C Source
RR RRR RR (%) RRR (%)
Retinopathy 0.462 0.538 0.025 0.029 2.5 2.9 DCCT, 199364
Nephropathy 0.611 0.389 0.033 0.021 3.3 2.1 DCCT, 199364
Neuropathy 0.390 0.610 0.021 0.033 2.1 3.3 DCCT, 199364
Cardiovascular disease 0.643 0.357 0.034 0.019 3.4 1.9 Martin et al, 201482
Severe hypoglycemiaa 1.13 −0.13 0.061 −0.007 6.1 −0.7 DCCT, 200976

Abbreviations: A1C, glycated hemoglobin; DCCT, Diabetes Control and Complications Trial; RR, relative risk; RRR, relative risk reduction.

a

The risk of severe hypoglycemia increases as A1C is reduced.