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Interference of rifampicin with oral anticoagulants. Our patient was treated with 1200 mg rifampicin daily over 14 days. Despite continuing anticoagulant therapy, antibiotic coadministration led to decreased INR levels. Fifteen days after the treatment with rifampicin ended, INR returned to therapeutic ranges. Average daily intake of phenprocoumon was 4.86 mg. INR, international normalised ratio.
