Table 2.
Comparison of amino acid alterations in gyrA, parC, and mexR with fluoroquinolone susceptibility of P. aeruginosa isolates
| Group of mutation | Amino acid alteration of
|
No. isolates with fluoroquinolone susceptibility
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
gyrA
|
parC
|
mexR
|
Susceptible | Intermediate | Resistant | ||||
| 83 | 133 | 87 | 141 | 25 | 126 | ||||
| ATCC 27853 | Thr (ACC) | Thr (ACG) | Ser (TCG) | Ser (AGC) | Ile (ATC) | Glu (GAG) | — | — | — |
| I | — | — | — | — | — | — | 11 | 05 | 02 |
| II | Ile (ATC) | Met (ATG) | — | — | — | — | 0 | 04 | 28 |
| III | — | — | Leu (TTG) | His (CAC) Thr (ACC) |
— | — | 0 | 0 | 09 |
| IV | — | — | — | — | Thr (ACC) Asn (AAC) |
Val (GTG) | 10 | 01 | 02 |
| V | Ile (ATC) | Met (ATG) | Leu (TTG) | His (CAC) Thr (ACC) |
— | — | 0 | 0 | 48 |
| VI | Ile (ATC) | Met (ATG) | Leu (TTG) | His (CAC) Thr (ACC) |
Thr (ACC) Asn (AAC) |
Val (GTG) | 0 | 0 | 05 |
| VII | Ile (ATC) | Met (ATG) | — | — | Thr (ACC) Asn (AAC) |
Val (GTG) | 0 | 0 | 10 |
| VIII | — | — | Leu (TTG) | His (CAC) Thr (ACC) |
Thr (ACC) Asn (AAC) |
Val (GTG) | 0 | 0 | 06 |
| Total | 21 | 10 | 110 | ||||||