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. Author manuscript; available in PMC: 2018 Mar 5.
Published in final edited form as: J Neuroimmune Pharmacol. 2011 Jun 14;6(4):585–596. doi: 10.1007/s11481-011-9284-5

FIGURE 6.

FIGURE 6

Chronic ICV IL-1β treatment, but not s.c. IL-1β inhibits the anti-SRBC AFC response. Rats (n=6/group) were given IL-1β (100 ng/day/kg), aCSF (CON) through ICV-implanted cannulas, or IL-1β (s.c.; 100 ng/day/kg) via s.c. miniosmotic pumps for 2 wk, and immunized with SRBC 4 days prior to sacrifice. The anti-SRBC AFC response of spleen cells was determined as described in Fig. 4. The graph represents mean ± SEM of AFC/106 spleen cells. * P ≤ 0.05.