FIGURE 7.

Chronic ICV exposure to IL-1β causes immunosuppression. Rats (n=6/group) were treated with IL-1β or aCSF(CON) for 2 wk as described in Fig. 6. Spleen cells were evaluated for Con A (A) and anti-TCR (B)-induced proliferative responses. (C) A representative profile of the spleen cell anti-TCR-induced [Ca2+]i response is shown as described in Fig. 5. Bar graphs are mean ± SEM. * P ≤ 0.05.