Table 1.

Eligibility criteria: All subjects in polypill arm, minimal care arm and those receiving usual care were assessed for inclusion criteria, but the exclusion criteria were only applied to minimal care and polypill arms.

Inclusion criteria Age over 50 years old Living in rural areas

Exclusion criteria Hypersensitivity to one of components of polypill (excluding cough due to enalapril) History of angioedema History of gastrointestinal bleeding or peptic ulcer disease within 3 months of eligibility assessment History of stroke Pregnancy or lactation Bleeding disorders such as hemophilia Regular anticoagulant use (excluding aspirin) Alcohol consumption more than 3 times a day Advanced liver diseases defined as history of chronic liver disease and platelet count lower than 100000/μL at the time of eligibility assessment Uncontrolled seizures defined as history of any seizure episode within 2 years of eligibility assessment either on or off the anticonvulsant treatment Presence of any of the followings in asthmatic patient: Daily symptoms Nighttime symptoms ≥ 1 night per week History of nasal polyposis Symptoms attributed to rhinitis without evidence of upper respiratory tract infection History of gout Serum creatinine > 2 mg/dL Glomerular filtration rate (GFR) < 30 ml/min Hemoglobin <10 mg/dL in females and <11 mg/dL in males Systolic blood pressure <90 mmHg and diastolic blood pressure < 60 mmHg Medical/psychiatric comorbidities potentially affecting the adherence of the participants: Major depression disorder, dementia, schizophrenia, manic-depressive bipolar disorder and other disorders with presentation of psychosis Cognitive impairments Blindness Inability to do diurnal activities independently eg wheelchair bound patients Disorientation with the study and its goals Unavailability of the subjects