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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: ACS Chem Biol. 2017 Nov 7;12(12):2946–2951. doi: 10.1021/acschembio.7b00813

Figure 1.

Figure 1

Fatty acyl-CoA synthetases and firefly luciferase catalyze similar, two-step reactions. (a) Firefly luciferase catalyzes the formation of an activated adenylate of D-luciferin followed by oxidation to an excited state oxyluciferin that is responsible for light emission. (b) Fatty acyl-CoA synthetases catalyze the formation of an activated adenylate of a free fatty acid followed by displacement of the adenylate by CoASH to form the acyl-CoA product. (c) A subset of synthetic luciferins emit light with CG6178 and/or AbLL in addition to firefly luciferase.