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. Author manuscript; available in PMC: 2018 Nov 22.
Published in final edited form as: J Med Chem. 2017 Nov 13;60(22):9239–9250. doi: 10.1021/acs.jmedchem.7b01113

Figure 1.

Figure 1

(A) The crystal structure of M2 active state in a complex with iperoxo (PDB 4MQS). Residues Asn6.52 and Asp3.32 are represented as sticks and hydrogen bonds as red broken lines. Iperoxo fits tightly in the binding site. (B–D) Docking poses of pilocarpine (B), muscarine (C), and arecoline (D) in the M2 active state structure.