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Activation of PINK1 by AMPKα2 Regulation of PINK1. A. Import of PINK1 into healthy mitochondria via the TOM/TIM import complex. PINK1 undergoes proteolytic cleavage by PARL and cleaved PINK1 retro-translocates to the cytosol where it is degraded by the proteasome. B. Upon mitochondrial damage, import of PINK1 is abrogated and it accumulates on the outer mitochondrial membrane which leads to its phosphorylation by AMPKα2.
