Table 1. P2 amplitude, P2 latency and N2 latency of visual evoked potential in normal rabbits with 1-month or 6-month dye-coupled film implantation and removal, and in rhodopsin-transgenic rabbits with 1-month dye-coupled film implantation.
| P2 amplitude in right eye (surgery) Mean ± SD (µV) |
P2 amplitude in left eye (control)
Mean ± SD (µV) |
Right eye/Left eye ratio of P2 amplitude | P2 latency in right eye (surgery)
Mean ± SD (msec) |
P2 latency in left eye (control)
Mean ± SD (msec) |
N2 latency in right eye (surgery)
Mean ± SD (msec) |
N2 latency in left eye (control) Mean ± SD (msec) |
|
|---|---|---|---|---|---|---|---|
| Normal rabbits with 1-month implantation | |||||||
| Pre-implantation | 2.51 ± 0.97 (n=4) | 2.18 ± 0.93 (n=4) | 1.21 ± 0.29 (n=4) | 90.2 ± 13.8 (n=4) | 84.5 ± 2.0 (n=4) | 75.5 ± 12.8 (n=4) | 69.5 ± 3.6 (n=4) |
| 1-month implantation | 1.55 ± 1.39 (n=4) | 2.18 ± 1.09 (n=4) | 1.20 ± 0.80 (n=4) | 89.2 ± 10.8 (n=4) | 92.5 ± 26.0 (n=4) | 79.2 ± 10.0 (n=4) | 65.2 ± 1.2 (n=4) |
| Paired t-test P value | P=0.0736 | P>0.9999 | P=0.9853 | P=0.8571 | P=0.5742 | P=0.3622 | P=0.1203 |
| Normal rabbits with 1-month implantation and removal | |||||||
| Pre-implantation | 4.67 ± 1.77 (n=4) | 4.30 ± 1.46 (n=4) | 1.16 ± 0.45 (n=4) | 90.0 ± 10.4 (n=4) | 86.0 ± 9.8 (n=4) | 63.7 ± 1.5 (n=4) | 64.7 ± 5.1 (n=4) |
| 1 month after removal | 1.55 ± 1.86 (n=3) | 3.63 ± 1.72 (n=3) | 0.79 ± 0.59 (n=3) | 83.3 ± 8.0 (n=3) | 97.6 ± 7.0 (n=3) | 74.3 ± 6.0 (n=3) | 74.0 ± 4.0 (n=3) |
| Paired t-test P value | P=0.1282 | P=0.3472 | P=0.4136 | P=0.8171 | P=0.1567 | P=0.1009 | P=0.0128 |
| Normal rabbits with 6-month implantation | |||||||
| Pre-implantation | 2.23 ± 0.20 (n=4) | 1.75 ± 0.80 (n=4) | 1.41 ± 0.42 (n=4) | 82.5 ± 1.9 (n=4) | 83.7 ± 2.9 (n=4) | 68.0 ± 5.7 (n=4) | 68.0 ± 6.1 (n=4) |
| 6-month implantation | 1.67 ± 0.88 (n=4) | 2.06 ± 0.39 (n=4) | 0.79 ± 0.38 (n=4) | 100.5 ± 22.4 (n=4) | 87.0 ± 11.4 (n=4) | 72.5 ± 12.7 (n=4) | 69.7 ± 12.5 (n=4) |
| Paired t-test P value | P=0.2805 | P=0.4908 | P=0.2119 | P=0.2110 | P=0.5222 | P=0.5934 | P=0.8310 |
| Normal rabbits with 6-month implantation and removal | |||||||
| Pre-implantation | 4.63 ± 2.83 (n=4) | 3.26 ± 1.24 (n=4) | 1.31 ± 0.63 (n=4) | 83.2 ± 4.9 (n=4) | 83.2 ± 2.7 (n=4) | 65.2 ± 3.8 (n=4) | 68.2 ± 3.5 (n=4) |
| 6 month implantation | 0.81 ± 0.33 (n=4) | 2.63 ± 0.53 (n=4) | 0.32 ± 0.16 (n=4) | 85.5 ± 4.5 (n=4) | 78.5 ± 4.7 (n=4) | 74.2 ± 5.8 (n=4) | 65.7 ± 4.5 (n=4) |
| 1 month after removal | 1.36 ± 0.38 (n=3) | 1.95 ± 0.48 (n=3) | 0.78 ± 0.48 (n=3) | 108.2 ± 30.5 (n=3) | 78.5 ± 2.6 (n=3) | 76.2 ± 9.2 (n=3) | 64.0 ± 2.1 (n=3) |
| Paired t-test P value (pre vs 6 month) | P=0.0668 | P=0.4486 | P=0.0595 | P=0.6289 | P=0.1169 | P=0.1432 | P=0.5696 |
| Paired t-test P value (pre vs removal) | P=0.2523 | P=0.2105 | P=0.4376 | P=0.2189 | P=0.0192 | P=0.1269 | P=0.1828 |
| Rhodopsin-transgenic rabbits with 1-month implantation | |||||||
| Pre-implantation | 1.46 ± 0.61 (n=4) | 1.86 ± 0.85 (n=4) | 0.86 ± 0.31 (n=4) | 78.7 ± 2.3 (n=4) | 83.0 ± 7.4 (n=4) | 69.0 ± 1.8 (n=4) | 72.7 ± 9.1 (n=4) |
| 1-month implantation | 0.86 ± 0.56 (n=4) | 1.67 ± 1.15 (n=4) | 0.82 ± 0.63 (n=4) | 96.5 ± 18.6 (n=4) | 95.7 ± 11.0 (n=4) | 73.2 ± 6.3 (n=4) | 80.5 ± 9.0 (n=4) |
| Paired t-test P value | P=0.0469 | P=0.8633 | P=0.9358 | P=0.1196 | P=0.1704 | P=0.3000 | P=0.1134 |
SD, standard deviation; µV, microvolt.