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. Author manuscript; available in PMC: 2019 Feb 4.
Published in final edited form as: Trends Mol Med. 2018 Feb 4;24(2):221–235. doi: 10.1016/j.molmed.2017.12.008

Figure 3. Genetic Associations with Nicotine Metabolism in the CYP2A6 Region of Human Chromosome 19.

Figure 3

The variants selected using penalized regression algorithms are overlaid on the marginal genetic association results (−log10 p-values on the y-axis). This shows how penalized regression algorithms can define biosignatures (red boxes) from complex patterns of marginal associations (stars).