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. Author manuscript; available in PMC: 2019 Feb 4.
Published in final edited form as: Trends Mol Med. 2018 Feb 4;24(2):221–235. doi: 10.1016/j.molmed.2017.12.008

Figure 6. Joint SNP Effects on Nicotine Metabolism.

Figure 6

The effects of combination of genetic variant on nicotine metabolism can be explored using Bayesian algorithms [58]. This plot shows that many genetic variants (dots) in different genes (color) can modify the effects of CYP2A6 variants on nicotine metabolism. This presents another way of defining biosignatures from a collection of models for use in prediction or generating new hypotheses.