Table 4.

Individual laboratory relative potency estimates (geometric mean) for ADCC assays.

		Versus IH Refb						Versus candidate (Sample A)
		Candidate (Sample A)			Sample C			Coded duplicate (Sample B)			Sample C
Methoda	Lab	GM	%GCV	n	GM	%GCV	n	GM	%GCV	n	GM	%GCV	n
ADCC-R	1	0.85	26	5	0.95	25	6	0.96	30	9	1.06	23	7
ADCC-NK	6	1.28	21	6	1.39	20	7	1.00	13	8	1.11	15	7
ADCC-R	7	1.46	27	15	1.73	16	7	0.99	17	9	1.32	29	6
ADCC-R	8	0.94	7	5	1.17	7	9	1.01	7	9	1.25	7	9
ADCC-NK	10	0.44	21	9	0.64	15	9	0.91	18	9	1.44	25	9
ADCC-P	11	Not available						1.03	33	7	1.60	21	7
ADCC-R	12	2.17	n/a	2	2.42	13	6	1.00	20	6	1.06	22	5
ADCC-NK	13	0.75	10	9	1.13	14	9	0.99	10	9	1.50	8	9
ADCC-P	14	Not available						0.92	25	3	1.48	13	4
ADCC-P	15	0.78	32	8	0.92	36	8	0.86	20	7	1.17	35	7
ADCC-DR	16	Not available						0.93	12	7	1.26	15	6

^aADCC-R and ADCC-DR indicate labs using a single or dual gene reporter assay, respectively and end-point killing based assays are shown as ADCC-NK and ADCC-P for assays using NK cell lines or primary cells, respectively; ^b

^b“In house” reference standard.