Table 2.

Known and candidate SNP markers of tumors in nonreproductive organs

Gene	dbSNP [6] rel. 147 or see [Ref]	5′ flank	wt mut	3′ flank	KD, nM					Known diseases (SNP markers) or hypothetical disease (candidate SNP markers)	[Ref] or [this work]
					wt mut	Δ	Z	α	ρ
IL1B	rs1143627	ttttgaaagc	c t	ataaaaacag	5 2	↑	15	10-6	A	high risks of gastric, liver, and non–small cell lung cancers; gastric ulcer, chronic gastritis, recurrent major depression, obesity, Graves’ disease, pre-eclampsia, (hypothetically) short time-to-delivery in pregnancy and childbirth	[77–85] [this work]
	rs549858786	tgaaagccat	a t	aaaacagcga	5 7	↓	8	10-6	A	(hypothetically) lesser risk of the same diseases	[60]
CYP2A6	rs28399433	tcaggcagta	t g	aaaggcaaac	2 9	↓	21	10-6	A	low risk of lung cancer in smokers (LUC: “-34g” corresponds to 50% of “-34t”), (hypothetically) lesser damage from secondhand smoke in pregnant women who are nonsmokers	[86, 87], [this work], [90–92]
	rs761592914	tttttcaggc	a c	gtataaaggc	2 3	↓	3	10-3	B	(hypothetically) the same disease	[this work]
CYP2B6	rs34223104	gatgaaattt	t c	ataacagggt	4 10	↓	15	10-6	A	TATAWT→USFSNP, TSSWT→TATASNP, and de-novo TSSSNP can cause overexpression of this gene of a bioactivator of immunosuppressive and antitumor prodrug cyclophosphamide	[88]
	rs563558831	tgaaatttta	t c	aacagggtgc	4 10	↓	13	10-6	A	(hypothetically) the same problem	[this work]
DHFR	rs10168	ctgcacaaat	g a	gggacgaggg	15 9	↑	9	10-6	A	resistance to methotrexate treatment of leukemia and (hypothetically) that in the cases of ectopic pregnancy, metastatic choriocarcinoma, and gestational trophoblastic disease	[89], [this work], [93]
	rs750793297	tgcacaaatg	g t	ggacgagggg	15 13	↑	3	10-2	C	(hypothetically) the same diseases	[this work]
	rs766799008	ctgcacaaat	a g	tggggacgag	15 19	↓	3	10-3	B	(hypothetically) greater bioactivity of methotrexate during treatment of leukemia, ectopic pregnancy, metastatic choriocarcinoma, and gestational trophoblastic disease	[this work], [60]
	rs764508464	ctgcacaaat	a -	tggggacgag	15 37	↓	17	10-6	A
	rs754122321	ctcgcctgca	c g	aaatggggac	15 25	↓	9	10-3	B

See “Note” under Table 1