Table 4.

Known and candidate reproductivity-related SNP markers in genes of other metabolic proteins

Gene	dbSNP [6] rel. 147 or see [Ref]	5′ flank	wt mut	3′ flank	KD, nM					Known diseases (SNP markers) or hypothetical disease (candidate SNP markers)	[Ref] or [this work]
					wt mut	Δ	Z	α	ρ
NOS2	-51t→c [288]	gtataaatac	t c	tcttggctgc	2 1	↑	3	10-2	C	resistance to malaria and epilepsy (hypothetically) higher risk of gestational diabetes mellitus	[288–290], [this work], [147]
STAR	rs16887226	cagccttcag	c t	gggggacatt	10 10	=	0	1	E	hypertensive diabetic patients, (EMSA: unknown TF-binding site lost rather than TATA box)	[291]
	rs544850971	tcagcggggg	a g	catttaagac	10 12	↓	5	10-2	C	(hypothetically) lower risk of the same disease and congenital adrenal hyperplasia	[this work], [148]
APOA1	35a→c [292]	tgcagacata	a c	ataggccctg	3 4	↓	5	10-6	A	fatty liver (hypothetically) high risk of polycystic ovary syndrome in young women	[292], [this work], [149]
CETP	DEL-51(18 bp) [293]	cgtgggggct	18bp -	gggctccagg	4 7	↓	7	10-6	A	hyperalphalipoproteinemia reducing risk of atherosclerosis	[293]
	rs17231520	ggggctgggc	g a	gacatacata	4 2	↑	10	10-6	A	(hypothetically) biomarker of late pregnancy when plasma triglyceride, high-density lipoprotein, and cholesterol concentrations are significantly increased	[this work], [150]
	rs569033466	atacatatac	g a	ggctccaggc	4 3	↑	4	10-3	B
	rs757176551	catatacggg	c g	tccaggctga	4 2	↑	10	10-6	A
SOD1	rs7277748	ggtctggcct	a g	taaagtagtc	2 7	↓	17	10-6	A	amyotrophic lateral sclerosis, (hypothetically), asthenospermia, lower female fertility via progesterone deficiency	[294], [this work], [151, 152]
TPI1	rs1800202	gcgctctata	t g	aagtgggcag	1 4	↓	17	10-6	B	hemolytic anemia, neuromuscular diseases	[295, 296]
										(hypothtically) higher risk of asthenospermia	[this work], [153]
	rs781835924	cgcggcgctc	t c	atataagtgg	1 2	↓	10	10-6	B
GJA5	rs10465885	caactaagat	g a	tattaaacac	3 3	=	1	1	E	arrhythmia, cardiovascular events (LUC: TF-binding site damaged, not TATA box)	[297]
										(hypothetically) the same disease and higher risk of heart morphogenesis disorders	[this work], [154]
	rs587745372	ggcgacagat	a t	cgattaaaaa	6 7	↓	3	10-3	B
	rs35594137	gaggagggaa	g a	gcgacagata	6 6	=	0	1	E
										arrhythmia, cardiovascular events (LUC: TF-binding site damaged, not TATA box)	[298]

See “Note” under Table 1