Skip to main content
. 2018 Feb 9;19(Suppl 3):0. doi: 10.1186/s12864-018-4478-3

Table 7.

Candidate SNP markers of reproductivity-related genes

Gene dbSNP [6] rel. 147 or see [Ref] 5′ flank wt
mut		 3′ flank KD, nM hypothetical disease (candidate SNP markers) [this work], [Ref]
wt
mut		 Δ Z α ρ
AR rs763353257 aagggaagta g
-		 gtggaagatt 30
21		 ↑ 6 10-6 A (hypothetically) higher risks of androgenetic alopecia and androgen-induced premature senescence in adult men [251]
rs749306567 aagggaagta g
a		 gtggaagatt 30
15		 ↑ 11 10-6 A
rs377711437 cagcactgca g
a		 ccacgacccg 75
66		 ↑ 2 0.05 D
MTHFR rs780207553 cacgcactct g
a		 ggcctgagct 74
38		 ↑ 12 10-6 A (hypothetically) higher risk of pre-eclampsia [252]
rs749532075 tccctcccca c
t*) 		gcactctggg 74
50		 ↑ 7 10-6 A
rs771960561 cctctgttcc c
t		 tccccacgca 74
66		 ↑ 3 10-2 B
rs773214376 tgcctctgtt c
t		 cctccccacg 74
66		 ↑ 2 0.05 D
rs566478202 ggtgcctctg t
g		 tccctcccca 74
85		 ↓ 2 0.05 D (hypothetically) higher risk of adverse pregnancy outcomes [253]
rs752181249 gaggatctac a
c		 gccatcagct 27
35		 ↓ 4 10-3 B
DNMT1 rs570287204 gtgggggggg -
gtg		 tgtgtgcccg 52
23		 ↑ 11 10-6 A (hypothetically) under stress, higher risk of epigenetic disorders of fetal and newborn brain development causing long-term neurobehavioral problems that may be reversible in adolescence [254, 255]
rs534819409 cgtggggggg g
t		 ggcctgagct 52
30		 ↑ 7 10-6 A
rs553454792 gcgtgggggg g
t		 gtgtgtgccc 52
23		 ↑ 11 10-6 A
rs558447661 cgtggagctt g
t		 gacgagccca 72
29		 ↑ 15 10-6 A
rs535899986 cccagcaaac c
t		 gtggagcttg 72
58		 ↑ 5 10-3 B
rs143796354 cacctcccag c
a		 aaaccgtgga 72
26		 ↑ 20 10-6 A
rs756103340 gcggcgcgca g
a		 cggcagttgg 92
79		 ↑ 3 10-3 B
rs758026532 ccagcaaacc g
t*) 		tggagcttgg 72
88		 ↓ 4 10-3 B (hypothetically) higher risks of activation of protooncogenes in cancer [256]
rs772821225 gtctccaata a
c		 atgcagctgg 7
8		 ↓ 2 0.05 D
CYP17A1 rs758657961 ctggagttga g
a		 ccagcccttg 56
30		 ↑ 11 10-6 A (hypothetically) higher risk of hyperandrogenism in polycystic ovary syndrome [257]
rs373488849 tgccctggag t
c		 tgagccagcc 56
70		 ↓ 4 10-3 B (hypothetically) higher risk of fertility impairments [258]
NR5A1 rs147497093 gttcagcaag c
t		 acaagagaaa 19
6		 ↑ 17 10-6 A (hypothetically) higher risks of adrenal tumors and endometriosis [259]
rs535432539 cgctgcttcc g
a		 cttcgtaagt 31
18		 ↑ 9 10-6 A
rs553326158 gcgctgcttc c
t		 gcttcgtaag 31
26		 ↑ 3 10-2 C
rs143242438 caccctcatc c
t		 ggtgtgagag 31
21		 ↑ 6 10-6 A

See the footnote of Table 1; *)this SNP includes one more minor neutral allele: “a.”