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. 2018 Feb 19;19(Suppl 1):45. doi: 10.1186/s12859-018-2014-8

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Four difference matrices. ΔH and ΔV represent the differences between horizontally and vertically adjacent cells in S. ΔE and ΔF are the differences between a pair of cells at the same i,j-coordinates in E and S, and F and S, respectively