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Change in mean ambulatory blood pressure measurements from baseline over treatment period. (a) Change in mean aSBP, (b) mean aDBP, and (c) mean aMAP measurements during sildenafil single dose treatment, sacubitril/valsartan steady state treatment, and coadministration of sacubitril/valsartan with sildenafil. aDBP, ambulatory diastolic blood pressure; aMAP, ambulatory mean arterial pressure; aSBP, ambulatory systolic blood pressure.
