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Change in geometric mean (95% CI) of biomarkers over various treatment periods. Change in creatinine‐indexed urine cGMP (a) and urine ANP (b) over 24‐h time period during sildenafil single dose, sacubitril/valsartan steady state treatment, and coadministration of sacubitril/valsartan and sildenafil. ANP, atrial natriuretic peptide; cGMP, cyclic guanosine monophosphate; CI, confidence interval.
