Table 3.
Statistical analysis of change in mean aSBP, aDBP, and aMAP from baseline over daytime, night time, and 24 h
| Time after dose |
Sildenafil vs. sacubitril/valsartan + sildenafil |
Sacubitril/valsartan vs. sacubitril/valsartan + sildenafil |
||
|---|---|---|---|---|
| Mean difference (95% CI) | P value |
Mean difference (95% CI) |
P value | |
| Mean aSBP (mm Hg) | ||||
| 0‐24 h | −17.0 (−20.72, −13.32) | <0.001 | −5.4 (−9.08, −1.68) | 0.005 |
| Day time | −18.3 (−21.96, −14.56) | <0.001 | −6.4 (−10.07, −2.67) | <0.001 |
| Night time | −16.9 (−20.58, −13.18) | <0.001 | −2.4 (−6.06, 1.34) | 0.210 |
| Mean aDBP (mm Hg) | ||||
| 0‐24 h | −9.8 (−12.22, −7.36) | <0.001 | −3.8 (−6.19, −1.34) | 0.003 |
| Day time | −10.3 (−12.72, −7.86) | <0.001 | −4.3 (−6.69, −1.84) | <0.001 |
| Night time | −10.5 (−12.90, −8.04) | <0.001 | −2.8 (−5.24, −0.38) | 0.024 |
| Mean aMAP (mm Hg) | ||||
| 0‐24 h | −11.9 (−14.63, −9.20) | <0.001 | −4.4 (−7.10, −1.67) | 0.002 |
| Day time | −12. 6 (−15.28, −9.84) | <0.001 | −5.1 (−7.85, −2.41) | <0.001 |
| Night time | −12.6 (−15.27, −9.83) | <0.001 | −2.5 (−5.25, 0.19) | 0.068 |
The 24‐h ABPM data were analyzed using repeated measures analysis‐of‐covariance model with treatment, hours postdose, and treatment by hours postdose interaction as fixed factors, patients as random factor, and time‐matched baseline as covariate.
aSBP, ambulatory systolic blood pressure; aDBP, ambulatory diastolic blood pressure; aMAP, ambulatory mean arterial pressure; CI, confidence interval.