Table 1.
Classification of GLP‐1RAs according to their pharmacokinetics, structure and size
| Pharmacokinetics | Structure | Size | |||
|---|---|---|---|---|---|
| Short‐acting | Continuous‐acting | Exendin‐4‐based | GLP‐1‐based | Small (<5 kDa) | Large (~63–73 kDa) |
| Exenatide twice daily14 | Albiglutide22 | Exenatide twice daily14 | Albiglutide22 | Exenatide twice daily14 | Albiglutide22 |
| Lixisenatide18 | Dulaglutide24 | Exenatide once weekly41 | Dulaglutide24 | Exenatide once weekly16 | Dulaglutide24 |
| Exenatide once weekly16 | ITCA 65029 | Liraglutide20 | ITCA 65029 | ||
| ITCA 65029 | Lixisenatide41 | Semaglutide26, 42 | Liraglutide20 | ||
| Liraglutide20 | Lixisenatide18 | ||||
| Semaglutide26, 42 | Semaglutidea 26, 42 | ||||
a
Precise molecular weight is not included in the cited references, but it is referred to as a small molecule.