Table 1.
Summary of PK parameters of plasma glucagon and PD parameters of plasma glucose
| PK parameters (glucagon) | Cohort 1 | Cohort 2 | |
|---|---|---|---|
| NG + Common cold (N = 18) | NG + No cold symptoms (N = 17) | NG + Common cold + Decongestant (N = 18) | |
| AUC0‐t, h·pg/mLa | 1198.4 (84.6) | 797.5 (50.1) | 1038.0 (60.7) |
| Cmax, pg/mLa | 1198.4 (83.0) | 801.5 (68.2) | 868.0 (68.8) |
| Tmax, minutesb | 18 (5, 90) | 18 (15, 40) | 18 (10, 60) |
| PD parameters (glucose) | |||
| AUEC0‐t, h·mmol/La | 17.0 (16.9) | 16.4 (13.4) | 19.0 (14.3) |
| Cmax, mmol/La | 8.0 (22.9) | 7.7 (19.4) | 8.8 (17.7) |
| Tmax, minutesb | 30 (15, 60) | 36 (20, 60) | 42 (20, 60) |
Abbreviations: AUC0‐t, area under the curve from time zero; AUEC0‐t, area under the effect curve from time zero; Cmax, maximum concentration; CV, coefficient of variation; NG, nasal glucagon; PD, pharmacodynamics; PK, pharmacokinetics; Tmax, time to maximum concentration; for glucose, 1 mmol/L = 18 mg/dL.
a
Arithmetic mean (CV%).
b
Median (minimum, maximum).