Table 2.

Comparison of plasma glucagon PK parameters and plasma glucose PD parameters

Comparison	Cohort 1 ‐ Common cold vs Cohort 2 ‐ Common cold + Decongestant			Cohort 1 ‐ Common cold vs Cohort 1 ‐ No cold symptoms
PK parameters (glucagon)	Estimated difference	P value	90% CI for difference of geometric means of transformed values	Estimated difference	P value	90% CI for difference of geometric means of transformed values
LnAUC0‐t (h·pg/mL)	0.010	0.967	−0.39, 0.415	0.230	0.331	−0.165, 0.625
LnCmax (pg/mL)	0.161	0.552	−0.294, 0.617	0.250	0.357	−0.210, 0.710
PD parameters (glucose)
LnAUEC0‐t, h·mmol/L	−0.116	0.023	−0.198, −0.034	0.038	0.132	−0.004, 0.079
LnCmax, mmol/L	0.114	0.109	−0.231, 0.003	−0.026	0.605	−0.060, 0.112

Abbreviations: AUC_0‐t, area under the curve from time zero; AUEC_0‐t, area under the effect curve from time zero; C_max, maximum concentration; CI, confidence interval; Ln, natural logarithm.