Table 3.
Relative change in the time to menarche and the time between thelarche and menarche associated with average pubertal AgeAccel in blood.
| HR (95% CI) |
|||
|---|---|---|---|
| Unadjusted | Adjusted 1a | Adjusted 2b | |
| Age at Thelarche (B2) | |||
| Continuous (per 5 years) | 0.99 (0.85, 1.16) | 0.96 (0.80, 1.16) | 0.99 (0.82, 1.20) |
| Categorical {ref: (−10, −2]} | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 1.17 (0.82, 1.69) | 1.21 (0.91, 1.62) | 1.20 (0.88, 1.63) |
| (2, 10] | 0.97 (0.72, 1.31) | 0.98 (0.69, 1.39) | 0.92 (0.65, 1.31) |
| Age at Menarche | |||
| Continuous (per 5 years) | 1.18 (0.96, 1.46) | 1.29* (1.03, 1.61) | 1.37* (1.04, 1.80) |
| Categorical {ref: (−10,−2]} | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 1.17 (0.79, 1.73) | 1.42* (1.01, 1.98) | 1.58 (1.00, 2.52) |
| (2, 10] | 1.42 (0.96, 2.08) | 1.61* (1.04, 2.49) | 1.77* (1.03, 3.03) |
| Pubertal Tempo | |||
| Continuous (per 5 years) | 1.26 (0.99, 1.59) | 1.35* (1.02, 1.79) | 1.48** (1.10, 1.99) |
| Categorical (ref: (−10, −2]) | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 0.90 (0.57, 1.41) | 1.11 (0.73, 1.69) | 1.15 (0.75, 1.76) |
| (2, 10] | 1.66* (1.07, 2.56) | 1.71* (1.00, 2.92) | 2.05** (1.20, 3.51) |
a
Adjusting for birth weight, maternal pre-pregnancy BMI, maternal height, maternal education, and cell-type distribution.
b
Adjusting for variables in Model 1 and child height Z-score and fat percentage at B2
*P<0.05, **P<0.01, ***P<0.001.