Figure 1.

HOX and epigenetic modifiers gene expression detected in AML patients.

The mRNA expression of HOXA, HOXB, histone demethylases (JMJD3, UTX) and DNA methyltransferases (DNMT3a, DNMT3b) was measured and normalized to that of a housekeeping gene (ABL1) (au – logarithmic values) in childhood AML patient samples (n = 46). The expression of the four gene sets was compared in RUNX1-RUNX1T1, CBF-MYH11, MLLr (MLL rearranged AML), neg (representing AML with a normal karyotype) and PML-RARα positive patient subgroups.