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. Author manuscript; available in PMC: 2018 May 8.
Published in final edited form as: Sci Transl Med. 2017 Nov 8;9(415):eaal2774. doi: 10.1126/scitranslmed.aal2774

Fig. 1. The cell-intrinsic fibroblast circadian proteome contains numerous cytoskeletal regulators.

Fig. 1

A. Protein annotation clusters generated by DAVID containing terms enriched (P <0.10) with rhythmic protein abundances identified by Rhythmicity Analysis Incorporating Nonparametric methods (RAIN) (P<0.01) from analysis of primary lung fibroblasts from PER2::LUC mice. B. The 10 largest Gene Ontology (GO) (cellular compartment) terms within the rhythmic dataset by protein number. C. Mean abundance (Light:Heavy (L:H) ratio) of rhythmic proteins from the ‘actin cytoskeleton’ cluster determined by 3 SILAC experiments with 3 parallel PER2::LUC measurements indicating the circadian phase (heat map).